In this work, we adopted an arbitrary Lagrangian and Eulerian FEM method (ALEF) with explicit dynamic solutions to simulate the expansion of brain mass effects caused by a pressure loading. One such challenge for the conventional Lagrangian frame based finite element method (LFEM) is that the mesh distortion resulted from the expansion of the mass effects can terminate the simulation prematurely before the desired pressure loading is achieved. A quantitative and sound measurement serving this particular purpose remains elusive due to multiple challenges associated with biomechanical modeling of the brain. Coupling with physiological parameters that are readily available using MRI, eg, tissue perfusion, a non-invasive, quantitative and regional estimation of intracranial stress distribution could offer a better understanding of brain tissue’s reaction under mass effect. Estimation of intracranial stress distribution caused by mass effect is critical to the management of hemorrhagic stroke or brain tumor patients, who may suffer severe secondary brain injury from brain tissue compression.
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